Navegação por autor "Acedo, Simone Coghetto"
Itens para a visualização no momento 1-4 de 4
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Effects of methotrexate on inflammatory alterations induced by obesity: An in vivo and in vitro study
Oliveira, Caroline Candida de; Acedo, Simone Coghetto; Gotardo, Érica Martins Ferreira; Carvalho, Patricia de Oliveira; Rocha, Thalita; Pedrazzoli, José; Gambero, Alessandra (Elsevier BV, 2012)Immunosuppressant drugs, such as methotrexate, are able to inhibit cytokine production and leukocyte migration to inflammatory foci; therefore, they could modify the establishment of inflammation in adipose tissue during ... -
Methotrexate is effective in reactivated colitis and reduces inflammatory alterations in mesenteric adipose tissue during intestinal inflammation
Thomaz, Marcia Aparecida; Acedo, Simone Coghetto; Oliveira, Caroline Candida de; Pereira, José Aires; Priolli, Denise Gonçalves; Saad, Mario José; Pedrazzoli, José; Gambero, Alessandra (Elsevier BV, 2009)Mesenteric white adipose tissue hypertrophy and modifications in adipocytokine production are described features of Crohn's disease. Experimentally, mesenteric white adipose tissue alterations, associated with intestinal ... -
Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk
Acedo, Simone Coghetto; Gambero, Sheley; Cunha, Fernanda Gonçalves Pereira; Lorand-Metze, Irene; Gambero, Alessandra (Springer Science and Business Media LLC, 2013)Macrophages develop into specialized cell types with special functional properties, depending on locally produced stimuli. Adipose tissue macrophages present particular characteristics, such as the M2 cell phenotype, and ... -
Perinodal adipose tissue and mesenteric lymph node activation during reactivated TNBS-colitis in rats
Acedo, Simone Coghetto; Gotardo, Érica Martins Ferreira; Lacerda, Janilda Martins; Oliveira, Caroline Candida de; Carvalho, Patrícia de Oliveira; Gambero, Alessandra (Springer Science and Business Media LLC, 2011)Background Colitis induced by trinitrobenzene sulfonic acid (TNBS) with reactivation is a good experimental model for studying inflammatory bowel disease pathogenesis and appropriate therapeutics. This experimental model ...