| dc.contributor.author | Barros, Pedro Paulo | |
| dc.contributor.author | Gonçalves, Gisele Mara Silva | |
| dc.contributor.author | Silva, Gustavo Henrique da | |
| dc.contributor.author | Bastos, Maria Clara Villaça Dias | |
| dc.contributor.author | Ramos, Loren Nogaroto | |
| dc.contributor.author | Fernandes, Marilia Marinello | |
| dc.date.accessioned | 2025-04-03T19:10:43Z | |
| dc.date.available | 2025-04-03T19:10:43Z | |
| dc.date.issued | 2018 | |
| dc.identifier.uri | http://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17732 | |
| dc.description.abstract | Purpose: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats.
Methods: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH.
Results: Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations.
Conclusion: Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery. | |
| dc.language.iso | Inglês | |
| dc.publisher | FapUNIFESP (SciELO) | pt_BR |
| dc.rights | Acesso aberto | pt_BR |
| dc.subject | Alanine Transaminase | |
| dc.subject | Aspartate Aminotransferases | |
| dc.subject | Apoptosis | |
| dc.subject | Mitotic Index | |
| dc.subject | Rats | |
| dc.title | Capsiate treatment in liver surgeries may compromise its recovery | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.contributor.institution | Pontifícia Universidade Católica de Campinas (PUC-Campinas) | pt_BR |
| dc.identifier.doi | https://doi.org/10.1590/s0102-865020180050000006 | pt_BR |
