| dc.description.abstract | Due to the rapid
spread of Sars-CoV-2 and COVID-19, at the
beginning of 2020, the state of a pandemic
by the coronavirus was installed and, since
then, incessant research is being carried out
in order to understand the pathophysiology
of the disease and identify possible elements
that predispose it. In this context, the
association of vitamin D with the installation
and progression of COVID-19 has been
studied. The justification for the proposal
of this work is due to the role of the vitamin
in the modulation of the immune system,
participating in the synthesis of catelecidin,
a peptide that reduces viral replication;
activation of defense cells; and the decrease
of inflammatory cytokines. Objectives: To
evaluate the plasma level of vitamin D, in
the active form calcitriol, in individuals
with COVID-19. Methods: Through a
bibliographic survey in the “PubMed”
database, with the keywords “COVID-19,
SARS-CoV-2, VITAMIN D, PREVENTION,
CONTROL, THERAPEUTIC USE”, 146
complete articles were collected and eight
were selected that showed the plasma
concentration of calcitriol in individuals
with COVID-19. Results: Analysis of the
eight articles resulted in the identification
of plasma levels of calcitriol in 1485
individuals with COVID-19. Of these, 82%
had Vitamin D values below the minimum
standard reference of 20 ng/mL. Conclusion:
Through the descriptive literature review, it
was concluded that the low plasma level of
vitamin D can be a risk factor for infections
by Sars-CoV-2 and an aggravating factor of
the clinical picture of COVID-19. | |
