Capsiate treatment in liver surgeries may compromise its recovery

Author
Barros, Pedro Paulo
Gonçalves, Gisele Mara Silva
Silva, Gustavo Henrique da
Bastos, Maria Clara Villaça Dias
Ramos, Loren Nogaroto
Fernandes, Marilia Marinello
Date
//2018
Content Type
Artigo
Access rights
Acesso aberto
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Abstract
Purpose: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH. Results: Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations. Conclusion: Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.
Keywords
Alanine Transaminase
Aspartate Aminotransferases
Apoptosis
Mitotic Index
Rats
Language
Inglês
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