Navegação por autor "Gambero, Alessandra"
Itens para a visualização no momento 1-20 de 38
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Acute inflammatory response induced by Helicobacter pylori in the rat air pouch
Gambero, Alessandra; Becker, Tagliane L.; Gurgueira, Sonia A.; Benvengo, Yune H.B.; Ribeiro, Marcelo L.; Mendonça, Sergio; Pedrazzoli, José (Oxford University Press (OUP), 2003)Infection by Helicobacter pylori elicits persistent neutrophil infiltration in the gastric mucosa and stimulates the release of substances that may contribute to the establishment of gastritis. In this study, we used the ... -
Addition of polyphenols to drugs: The potential of controlling “inflammaging” and fibrosis in human senescent lung fibroblasts in vitro
Godoy, Maria Carolina Ximenes de; Monteiro, Gabriela Arruda; Moraes, Bárbara Hakim de; Macedo, Juliana Alves; Gonçalves, Gisele Mara Silva; Gambero, Alessandra (MDPI AG, 2024)The combination of a polyphenol, quercetin, with dasatinib initiated clinical trials to evaluate the safety and efficacy of senolytics in idiopathic pulmonary fibrosis, a lung disease associated with the presence of senescent ... -
Anti-inflammatory effects of yerba maté extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity
Arçari, Demétrius P.; Bartchewsky, Waldemar; Santos, Tanila W. dos; Oliveira, Karim A.; Oliveira, Carlorine C. de; Gotardo, Érica M.; Pedrazzoli, José; Gambero, Alessandra; Ferraz, Lucio F.C.; Carvalho, Patricia de O.; Ribeiro, Marcelo L. (Elsevier BV, 2011)The aim of the present study was to evaluate the effects of yerba maté extract upon markers of insulin resistance and inflammatory markers in mice with high fat diet-induced obesity. The mice were introduced to either ... -
Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet–induced obese mice
Arçari, Demétrius P.; Bartchewsky, Waldemar; Santos, Tanila W. dos; Oliveira, Karim A.; Funck, Alexandre; Pedrazzoli, José; Souza, Marina F.F. de; Saad, Mario J.; Bastos, Deborah H.M.; Gambero, Alessandra; Carvalho, Patricia de O.; Ribeiro, Marcelo L. (Wiley, 2009)Because the potential of yerba maté (Ilex paraguariensis) has been suggested in the management of obesity, the aim of the present study was to evaluate the effects of yerba maté extract on weight loss, obesity-related ... -
Avaliação do potencial senostático de combinações de fármacos e polifenóis
Moraes, Bárbara Hakim de (Pontifícia Universidade Católica de Campinas (PUC-Campinas), 2023-12-18)A células senescentes estão associadas ao envelhecimento, se acumulam nos tecidos e são responsáveis por diversas doenças que causam mortalidade e morbidade. Elas são caracterizadas por apresentar um fenótipo secretor, ... -
Bioaccessibility evaluation of soymilk isoflavones with biotransformation processing
Macedo, Gabriela Alves; Caria, Cíntia Rabelo e Paiva; Barbosa, Paula de Paula Menezes; Mazine, Marina Rodrigues; Gambero, Alessandra (MDPI AG, 2023)Soy isoflavones are considered important sources of bioactive compounds, but they are poorly absorbable, due to their large hydrophilic structures. Some biotransformation strategies have been used to convert the glycosidic ... -
Biotransformed citrus extract as a source of anti-inflammatory polyphenols: Effects in macrophages and adipocytes
Nakajima, Vânia Mayumi; Moala, Tais; Caria, Cintia Rabelo e Paiva; Moura, Carolina Soares; Amaya-Farfan, Jaime; Gambero, Alessandra; Macedo, Gabriela Alves; Macedo, Juliana Alves (Elsevier BV, 2017)Chronic non-communicable diseases such as obesity are preceded by increased macrophage infiltration in adipose tissue and greater secretion of pro-inflammatory cytokines. We evaluated the anti-inflammatory potential of ... -
Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors
Gambero, Alessandra; Becker, Tagliane Liza; Zago, Andréa Silva; Oliveira, Andréa Fermino; Pedrazzoli, José (Springer Science and Business Media LLC, 2005)The aim of the present work was to study the in vivo anti-inflammatory activity of six NSAIDs, ibuprofen, diclofenac, nimesulide, meloxicam, celecoxib and rofecoxib, using the rat air-pouch model of inflammation to ... -
Could new palm-free structured lipids mitigate postprandial hyperlipidemia and inflammation induced by high-fat meals in swiss mice?
Malveira, Alice da Silva; Alves, Vanessa; Chiocchetti, Gabriela de Matuoka e; Gambero, Alessandra; Ávila, Amanda Rejane Alves de; Furtado, Guilherme de Figueiredo; Macedo, Juliana Alves; Luccas, Valdecir; Macedo, Gabriela Alves (Informa UK Limited, 2025)A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants. Objective: We evaluated ... -
Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol
Gambero, Alessandra; Maróstica, Marta; Becker, Tagliane Liza; Jr., José Pedrazzoli (Springer Science and Business Media LLC, 2007)In this study, we evaluated the effect of two different dosages of therapeutically prescribed nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, diclofenac, nimesulide, meloxicam, and celecoxib (ED80 for COX-1 and ... -
Effects of grape pomace extracts in hepatic steatosis, uma avaliação in vitro
Rubia, Camila; Macedo, Juliana Alves; Gambero, Alessandra (Editora Científica Digital, 2020)A doença hepática gordurosa não-alcoólica (DHGNA) é uma das doenças hepáticas mais comuns no mundo. A esteatose hepática, basicamente, pode ser definida como o acúmulo de lipídios no fígado. Os compostos fenólicos dos ... -
Effects of iron supplementation in mice with hypoferremia induced by obesity
Gotardo, Érica Martins Ferreira; Caria, Cintia Rabelo e Paiva; Oliveira, Caroline Candida de; Rocha, Thalita; Ribeiro, Marcelo Lima; Gambero, Alessandra (Frontiers Media SA, 2016)Iron is an important micronutrient, but it can also act as a dangerous element by interfering with glucose homeostasis and inflammation, two features that are already disturbed in obese subjects. In this work, we study the ... -
Effects of methotrexate on inflammatory alterations induced by obesity: An in vivo and in vitro study
Oliveira, Caroline Candida de; Acedo, Simone Coghetto; Gotardo, Érica Martins Ferreira; Carvalho, Patricia de Oliveira; Rocha, Thalita; Pedrazzoli, José; Gambero, Alessandra (Elsevier BV, 2012)Immunosuppressant drugs, such as methotrexate, are able to inhibit cytokine production and leukocyte migration to inflammatory foci; therefore, they could modify the establishment of inflammation in adipose tissue during ... -
Effects of polyphenols on thermogenesis and mitochondrial biogenesis
Santos, Tanila Wood dos; Pereira, Quélita Cristina; Teixeira, Lucimara; Gambero, Alessandra; Villena, Josep A.; Ribeiro, Marcelo Lima (MDPI AG, 2018)Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity ... -
Effects of systemic inflammation due to hepatic ischemia-reperfusion injury upon lean or obese visceral adipose tissue
Ferraz, Ligia Fernanda; Caria, Cintia Rabelo e Paiva; Santos, Raquel de Cássia; Ribeiro, Marcelo Lima; Gambero, Alessandra (FapUNIFESP (SciELO), 2022)Purpose: To evaluate how the induction of liver damage by ischemia and reperfusion affects the adipose tissue of lean and obese mice. Methods: Lean and diet-induced obese mice were subjected to liver ischemia (30 min) ... -
Effects of Yerba maté, a plant extract formulation (“YGD”) and resveratrol in 3T3-L1 adipogenesis
Santos, Juliana; Gotardo, Érica; Brianti, Mitsue; Piraee, Mahmood; Gambero, Alessandra; Ribeiro, Marcelo (MDPI AG, 2014)We aimed to evaluate the in vitro effects of yerba maté, YGD (a herbal preparation containing yerba maté, guarana and damiana), and resveratrol on adipogenesis. The anti-adipogenic effects of yerba mate, YGD, resveratrol ... -
Evaluation of Budesonide–hydroxypropyl-β-cyclodextrin inclusion complex in thermoreversible gels for ulcerative colitis
Lázaro, Carolina Martins; Oliveira, Carolina C. de; Gambero, Alessandra; Rocha, Thalita; Cereda, Cintia Maria Saia; Araújo, Daniele Ribeiro de; Tofoli, Giovana Radomille (Springer Science and Business Media LLC, 2020)Background New formulations for topical treatment of ulcerative colitis with budesonide inclusion complex (BUDHP-β-CD) and poloxamers (PL) were developed for future clinical use. Aims This study evaluated the efcacy of ... -
Evaluation of structured lipids with behenic acid in the prevention of obesity
Moreira, Débora Kono Taketa; Santos, Paola Souza; Gambero, Alessandra; Macedo, Gabriela Alves (Elsevier BV, 2017)Obesity affects all social classes, making it necessary to develop effective products that aid weight loss or help prevent weight gain. The objective of this work was to study the anti-obesity effects of structured lipids ... -
Expression of Toll-Like receptors in enterocromaffin-like cells and their function in histamine release
Stefani, Carolina Bernardi; Oliveira, Rafael Martins de; Silveira, Angélica Aparecida Antoniellis; Ferraz, Lucio Fabio Caldas; Ribeiro, Marcelo Lima; Gambero, Alessandra; Pedrazzoli , Júnior, José (Springer Science and Business Media LLC, 2012)Introduction Enterocromaffin-like cells (ECL) are specialized endocrine gastric cells able to release histamine, which in turn controls gastric acid production by parietal cells. Helicobacter pylori infection and other ... -
Hepcidin and inflammation associated with iron deficiency in childhood obesity - A systematic review
Berton, Pedro Ferro; Gambero, Alessandra (Elsevier BV, 2024)Objectives This paper aims to review data on the association of obesity and iron deficiency in children and adolescents, exposing the possible involvement of hepcidin and interleukin-6 (IL-6), obesity's inflammation ...