dc.contributor.author | Santos, Juliana Carvalho | |
dc.contributor.author | Ribeiro, Marcelo Lima | |
dc.contributor.author | Gambero, Alessandra | |
dc.date.accessioned | 2024-03-27T13:58:50Z | |
dc.date.available | 2024-03-27T13:58:50Z | |
dc.date.issued | 2021-01-12 | |
dc.identifier.uri | http://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17229 | |
dc.description.abstract | The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity. | pt_BR |
dc.language.iso | eng | pt_BR |
dc.publisher | Frontiers in Physiology | pt_BR |
dc.rights | Acesso aberto | pt_BR |
dc.subject | COVID-19 | pt_BR |
dc.subject | cytokine storm | pt_BR |
dc.subject | inflammation | pt_BR |
dc.subject | senescence | pt_BR |
dc.subject | polyphenols | pt_BR |
dc.title | The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients | pt_BR |
dc.title.alternative | O impacto da dieta à base de polifenóis no perfil inflamatório em pacientes idosos e obesos com COVID-19 | pt_BR |
dc.type | Artigo | pt_BR |
dc.contributor.institution | Pontifícia Universidade Católica de Campinas (PUC-Campinas) | pt_BR |
dc.identifier.lattes | 3745130367978210 | pt_BR |
dc.identifier.lattes | 3907210235081483 | pt_BR |
dc.identifier.lattes | 7165708428659026 | pt_BR |
puc.center | Escola de Ciências da Vida | pt_BR |
puc.graduateProgram | Ciências da Saúde | pt_BR |
puc.embargo | Online | pt_BR |
puc.undergraduateProgram | Não se aplica | pt_BR |